| Title : Arisugacins C and D, novel acetylcholinesterase inhibitors and their related novel metabolites produced by Penicilium sp. FO-4259-11 - Otoguro_2000_J.Antibiot.(Tokyo)_53_50 |
| Author(s) : Otoguro K , Shiomi K , Yamaguchi Y , Arai N , Sunazuka T , Masuma R , Iwai Y , Omura S |
| Ref : J Antibiot (Tokyo) , 53 :50 , 2000 |
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Abstract :
The mutant of Penicillium sp. FO-4259, an arisugacins A and B producing strain, was found to produce a series of metabolites, designated arisugacins C, D, E, F, G and H, which were structurally related to arisugacins A and B. These compounds were isolated from the culture broth and the physico-chemical and biological properties were examined. The IC50 values of arisugacins C and D against acetylcholinesterase (AChE) were 2.5 microM and 3.5 microM, respectively. However arisugacins E, F, G and H did not inhibit AChE at 100 microM. Though they showed only weak or no activity against AChE compared with arisugacins A and B, they may be useful for the study of the structure-activity relationship. |
| PubMedSearch : Otoguro_2000_J.Antibiot.(Tokyo)_53_50 |
| PubMedID: 10724008 |
Otoguro K, Shiomi K, Yamaguchi Y, Arai N, Sunazuka T, Masuma R, Iwai Y, Omura S (2000)
Arisugacins C and D, novel acetylcholinesterase inhibitors and their related novel metabolites produced by Penicilium sp. FO-4259-11
J Antibiot (Tokyo)
53 :50
Otoguro K, Shiomi K, Yamaguchi Y, Arai N, Sunazuka T, Masuma R, Iwai Y, Omura S (2000)
J Antibiot (Tokyo)
53 :50