Overstreet_1986_Psychopharmacology.(Berl)_88_129

Reference

Title : Enhanced elevation of corticosterone following arecoline administration to rats selectively bred for increased cholinergic function - Overstreet_1986_Psychopharmacology.(Berl)_88_129
Author(s) : Overstreet DH , Booth RA , Dana R , Risch SC , Janowsky DS
Ref : Psychopharmacology (Berl) , 88 :129 , 1986
Abstract :

Serum corticosterone levels were determined following administration of the cholinergic agonist arecoline (4 mg/kg) to rats selectively bred for differences in cholinergic function. The Flinders Sensitive Line (FSL) of rats exhibited both greater suppression of behavioural activity and enhanced elevation fo serum corticosterone than the Flinders Resistant Line of rats. These enhanced responses to arecoline in the FSL rats parallel those reported in depressed humans, suggesting that these rats may provide a new animal model of affective disorders.

PubMedSearch : Overstreet_1986_Psychopharmacology.(Berl)_88_129
PubMedID: 3080772

Related information

Substrate Arecoline

Citations formats

Overstreet DH, Booth RA, Dana R, Risch SC, Janowsky DS (1986)
Enhanced elevation of corticosterone following arecoline administration to rats selectively bred for increased cholinergic function
Psychopharmacology (Berl) 88 :129

Overstreet DH, Booth RA, Dana R, Risch SC, Janowsky DS (1986)
Psychopharmacology (Berl) 88 :129