Ozaslan_2022_Chem.Biodivers__e202200280

In the current study, some phenolic compounds, including acteoside, isoacteoside, echinacoside, and arenarioside purified and characterized from Plantago subulata. These compounds were tested for its antioxidant potential, including Fe(3+) and Cu(2+) reductive ability and Fe(2+) chelating effects. The inhibitory effects of isolated phenolic compounds were tested towards human carbonic anhydrase I and II isoenzymes (hCAI and hCAII), butyrylcholinesterase (BChE) acetylcholinesterase (AChE), aldose reductase (AR) and alpha-glycosidase (alpha-gly). K(i) values were found these compounds in range of 0.24+/-0.05-1.38+/-0.34microM against hCAI, 0.194+/-0.018-1.03+/-0.06microM against hCAII, 0.043+/-0.01-0.154+/-0.02microM against AChE, 3.92+/-1.08-11.93+/-4.45microM against BChE, 0.082+/-0.0008-1.68+/-0.42microM against AR, and 6.93+/-2.74-17.17+/-6.70microM against alpha-glycosidase. As a result, isolated compounds displayed inhibition effects against studied all metabolic enzymes. They are promising candidates for treating disorders like Alzheimer's disease, diabetes mellitus, glaucoma, leukemia, and epilepsy.