| Title : Whole-genome sequencing identifies emergence of a quinolone resistance mutation in a case of Stenotrophomonas maltophilia bacteremia - Pak_2015_Antimicrob.Agents.Chemother_59_7117 |
| Author(s) : Pak TR , Altman DR , Attie O , Sebra R , Hamula CL , Lewis M , Deikus G , Newman LC , Fang G , Hand J , Patel G , Wallach F , Schadt EE , Huprikar S , van Bakel H , Kasarskis A , Bashir A |
| Ref : Antimicrobial Agents & Chemotherapy , 59 :7117 , 2015 |
|
Abstract :
Whole-genome sequences for Stenotrophomonas maltophilia serial isolates from a bacteremic patient before and after development of levofloxacin resistance were assembled de novo and differed by one single-nucleotide variant in smeT, a repressor for multidrug efflux operon smeDEF. Along with sequenced isolates from five contemporaneous cases, they displayed considerable diversity compared against all published complete genomes. Whole-genome sequencing and complete assembly can conclusively identify resistance mechanisms emerging in S. maltophilia strains during clinical therapy. |
| PubMedSearch : Pak_2015_Antimicrob.Agents.Chemother_59_7117 |
| PubMedID: 26324280 |
| Gene_locus related to this paper: stema-a0a0k2iyn7 , stema-a0a0m0p330 |
| Gene_locus | stema-a0a0k2iyn7 stema-a0a0m0p330 |
Pak TR, Altman DR, Attie O, Sebra R, Hamula CL, Lewis M, Deikus G, Newman LC, Fang G, Hand J, Patel G, Wallach F, Schadt EE, Huprikar S, van Bakel H, Kasarskis A, Bashir A (2015)
Whole-genome sequencing identifies emergence of a quinolone resistance mutation in a case of Stenotrophomonas maltophilia bacteremia
Antimicrobial Agents & Chemotherapy
59 :7117
Pak TR, Altman DR, Attie O, Sebra R, Hamula CL, Lewis M, Deikus G, Newman LC, Fang G, Hand J, Patel G, Wallach F, Schadt EE, Huprikar S, van Bakel H, Kasarskis A, Bashir A (2015)
Antimicrobial Agents & Chemotherapy
59 :7117