Title : Allosteric modulators of the alpha4beta2 subtype of neuronal nicotinic acetylcholine receptors - Pandya_2011_Biochem.Pharmacol_82(8)_952 |
Author(s) : Pandya A , Yakel JL |
Ref : Biochemical Pharmacology , 82 :952 , 2011 |
Abstract :
Nicotinic acetylcholine receptors are ligand-gated ion conducting transmembrane channels from the Cys-loop receptor super-family. The alpha4beta2 subtype is the predominant heteromeric subtype of nicotinic receptors found in the brain. Allosteric modulators for alpha4beta2 receptors interact at a site other than the orthosteric site where acetylcholine binds. Many compounds which act as allosteric modulators of the alpha4beta2 receptors have been identified, with both positive and negative effects. Such allosteric modulators either increase or decrease the response induced by agonist on the alpha4beta2 receptors. Here we discuss the concept of allosterism as it pertains to the alpha4beta2 receptors and summarize the important features of allosteric modulators for this nicotinic receptor subtype. |
PubMedSearch : Pandya_2011_Biochem.Pharmacol_82(8)_952 |
PubMedID: 21596025 |
Pandya A, Yakel JL (2011)
Allosteric modulators of the alpha4beta2 subtype of neuronal nicotinic acetylcholine receptors
Biochemical Pharmacology
82 :952
Pandya A, Yakel JL (2011)
Biochemical Pharmacology
82 :952