| Title : A new HPLC method to determine Donepezil hydrochloride in tablets - Pappa_2002_J.Pharm.Biomed.Anal_27_177 |
| Author(s) : Pappa H , Farru R , Vilanova PO , Palacios M , Pizzorno MT |
| Ref : J Pharm Biomed Anal , 27 :177 , 2002 |
|
Abstract :
A HPLC stability-indicating assay for Donepezil hydrochloride in tablets was developed and validated. Donepezil hydrochloride is a reversible inhibitor of acetylcholinesterase, indicated for the treatment of mild to moderate dementia of the Alzheimer's type. The HPLC method was performed with a reversed phase C18 column, detection at 268 nm and a mixture of methanol, phosphate buffer 0.02 M and triethylamine (50:50:0.5) as mobile phase. Typical retention time for Donepezil was 9 min. The method was statistically validated for linearity, accuracy, precision and selectivity following ICH recommendations. Due to its simplicity and accuracy, the method can be used for routine quality control analysis. |
| PubMedSearch : Pappa_2002_J.Pharm.Biomed.Anal_27_177 |
| PubMedID: 11682224 |
Pappa H, Farru R, Vilanova PO, Palacios M, Pizzorno MT (2002)
A new HPLC method to determine Donepezil hydrochloride in tablets
J Pharm Biomed Anal
27 :177
Pappa H, Farru R, Vilanova PO, Palacios M, Pizzorno MT (2002)
J Pharm Biomed Anal
27 :177