| Title : Outcome and Safety after 103 Radioembolizations with Yttrium-90 Resin Microspheres in 73 Patients with Unresectable Intrahepatic Cholangiocarcinoma-An Evaluation of Predictors - Paprottka_2021_Cancers.(Basel)_13_ |
| Author(s) : Paprottka KJ , Galie F , Ingrisch M , Geith T , Ilhan H , Todica A , Michl M , Nadjiri J , Paprottka PM |
| Ref : Cancers (Basel) , 13 : , 2021 |
| Abstract : Trans-arterial radioembolization (TARE) is increasingly evaluated for unresectable intrahepatic cholangiocarcinoma (ICC). Not all ICC patients benefit equally well from TARE. Therefore, we sought to evaluate variables predicting progression-free survival (PFS) and overall survival (OS). Patients with non-resectable ICC underwent TARE and were treated with 90Y resin microspheres. Baseline characteristics, biochemical/clinical toxicities, and response were examined for impact on PFS and OS. A total of 103 treatments were administered to 73 patients without major complications or toxicity. Mean OS was 18.9 months (95% confidence intervals (CI); 13.9-23.9 months). Mean and median PFS were 10.1 months (95% CI; 7.9-12.2) and 6.4 months (95% CI; 5.20-7.61), respectively. Median OS and PFS were significantly prolonged in patients with baseline cholinesterase (CHE) <= 4.62 kU/L (OS: 14.0 vs. 5.5 months; PFS: 6.9 vs. 3.2 months; p < 0.001). Patients with a tumor burden >= 25% had a significantly longer OS (15.2 vs. 6.6 months; p = 0.036). Median PFS was significantly longer for patients with multiple TARE cycles (24.4 vs. 5.8 months; p = 0.04). TARE is a considerable and safe option for unresectable ICC. CA-19-9, CHE, and tumor burden have predictive value for survival in patients treated with TARE. Multiple TARE treatments might further improve survival; this has to be confirmed by further studies. |
| ESTHER : Paprottka_2021_Cancers.(Basel)_13_ |
| PubMedSearch : Paprottka_2021_Cancers.(Basel)_13_ |
| PubMedID: 34771563 |
Paprottka KJ, Galie F, Ingrisch M, Geith T, Ilhan H, Todica A, Michl M, Nadjiri J, Paprottka PM (2021)
Outcome and Safety after 103 Radioembolizations with Yttrium-90 Resin Microspheres in 73 Patients with Unresectable Intrahepatic Cholangiocarcinoma-An Evaluation of Predictors
Cancers (Basel)
13 :
Paprottka KJ, Galie F, Ingrisch M, Geith T, Ilhan H, Todica A, Michl M, Nadjiri J, Paprottka PM (2021)
Cancers (Basel)
13 :