| Title : Isolation and the fluorometric, high-performance liquid chromatographic determination of tacrine - Park_1986_Anal.Biochem_159_358 |
| Author(s) : Park TH , Tachiki KH , Summers WK , Kling D , Fitten J , Perryman K , Spidell K , Kling AS |
| Ref : Analytical Biochemistry , 159 :358 , 1986 |
|
Abstract :
Tacrine (THA; 1,2,3,4-tetrahydro-9-aminoacridine) is an anticholinesterase agent which has been used clinically, most recently in the treatment of Alzheimer-type dementias. This paper describes the methodology for the isolation and quantitation of THA at therapeutic levels in serum from human subjects. Using C18 Bond Elut columns and an HPLC/fluorometry system, this assay exhibits a considerable improvement in sensitivity over previous uv methods, and allows routine testing of THA levels in serum samples of reasonable volume from human subjects. |
| PubMedSearch : Park_1986_Anal.Biochem_159_358 |
| PubMedID: 3103482 |
Park TH, Tachiki KH, Summers WK, Kling D, Fitten J, Perryman K, Spidell K, Kling AS (1986)
Isolation and the fluorometric, high-performance liquid chromatographic determination of tacrine
Analytical Biochemistry
159 :358
Park TH, Tachiki KH, Summers WK, Kling D, Fitten J, Perryman K, Spidell K, Kling AS (1986)
Analytical Biochemistry
159 :358