Title : Carbachol induces a form of long-term potentiation in lateral amygdala - Park_2004_Neuroreport_15_1339 |
Author(s) : Park EJ , Nam RH , Choi S , Lee CJ |
Ref : Neuroreport , 15 :1339 , 2004 |
Abstract :
We examined the effects of carbachol, a muscarinic acetylcholine receptor agonist, on excitatory synaptic transmission at thalamo-amygdala synapses in rat brain slices. The application of a low concentration of carbachol (0.25 microM) produced a form of long-term potentiation (cLTP) and a transient suppression of synaptic responses, which was blocked by a muscarinic receptor antagonist, atropine (10 microM). M2 receptor agonist produced only a transient suppression, whereas M1 receptor agonist induced both a transient suppression and a long-term potentiation. Induction of cLTP required simultaneous low-frequency afferent stimulation, and was also dependent upon the activation of NMDA receptors. SQ22536 (50 microM), an adenylyl cyclase inhibitor completely blocked cLTP. Consistently, pretreatment with a maximal concentration of forskolin (10 microM) reduced cLTP. |
PubMedSearch : Park_2004_Neuroreport_15_1339 |
PubMedID: 15167562 |
Park EJ, Nam RH, Choi S, Lee CJ (2004)
Carbachol induces a form of long-term potentiation in lateral amygdala
Neuroreport
15 :1339
Park EJ, Nam RH, Choi S, Lee CJ (2004)
Neuroreport
15 :1339