| Title : Mechanisms of hepatotoxicity caused by dacarbazine in rats - Paschke_1993_J.Cancer.Res.Clin.Onc_119_475 |
| Author(s) : Paschke R , Heine M , Braun S , Usadel KH |
| Ref : Journal of Cancer Research & Clinical Oncology , 119 :475 , 1993 |
| Abstract : Possible risks of fatal dacarbazine hepatotoxicity have not been studied systematically. We therefore asked whether dacarbazine hepatotoxicity is influenced by the dose or mode of application, by dacarbazine light-decay products, by prior liver damage or by an induction of dacarbazine metabolism. 22 Sprague-Dawley rats were treated with 4.5 mg and 200 mg dacarbazine/kg bodyweight i.p. and i.v., with dacarbazine light-decay products and with 4.5 mg and 200 mg dacarbazine/kg bodymass after previous galactosamine and ethanol treatment. Serum alanine aminotransferase, cholinesterase and white blood cell and platelet numbers were measured and liver histology was evaluated. Dose-dependent dacarbazine hepatotoxicity could be demonstrated by histology. The mode of application, dacarbazine light-decay products and acute liver damage did not influence dacarbazine hepatotoxicity. However 200 mg dacarbazine/kg bodymass after ethanol pretreatment caused significant serological changes and a significant leucodepression. The increased hepato- and myelotoxicity after induction of hepatic microsomal enzymes should be reason to exclude ethanol and drugs that induce hepatic microsomal enzymes prior to treatment with dacarbazine. |
| ESTHER : Paschke_1993_J.Cancer.Res.Clin.Onc_119_475 |
| PubMedSearch : Paschke_1993_J.Cancer.Res.Clin.Onc_119_475 |
| PubMedID: 8509437 |
Paschke R, Heine M, Braun S, Usadel KH (1993)
Mechanisms of hepatotoxicity caused by dacarbazine in rats
Journal of Cancer Research & Clinical Oncology
119 :475
Paschke R, Heine M, Braun S, Usadel KH (1993)
Journal of Cancer Research & Clinical Oncology
119 :475