Paskus_2019_Cell.Rep_29_2944

Reference

Title : Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action - Paskus_2019_Cell.Rep_29_2944
Author(s) : Paskus JD , Tian C , Fingleton E , Shen C , Chen X , Li Y , Myers SA , Badger JD, 2nd , Bemben MA , Herring BE , Roche KW
Ref : Cell Rep , 29 :2944 , 2019
Abstract :

The RhoGEFs Kalirin-7 and Trio are regulators of synaptic plasticity, and their dysregulation is associated with a range of neurodevelopmental and neurodegenerative disorders. Although studies have implicated both Kalirin and Trio in certain diseases, such as tauopathies, they remarkably differ in their association with other disorders. Using unbiased proteomics, we identified interactomes of Kalirin-7 and Trio to ascertain distinct protein association networks associated with their respective function and revealed groups of proteins that preferentially interact with a particular RhoGEF. In comparison, we find Trio interacts with a range of axon guidance and presynaptic complexes, whereas Kalirin-7 associates with several synaptic adhesion molecules. Specifically, we show Kalirin-7 is an interactor of the cell adhesion molecule neuroligin-1 (NLGN1), and NLGN1-dependent synaptic function is mediated through Kalirin-7 in an interaction-dependent manner. Our data reveal not only the interactomes of two important disease-related proteins, but also provide an intracellular effector of NLGN1 function.

PubMedSearch : Paskus_2019_Cell.Rep_29_2944
PubMedID: 31801062

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Citations formats

Paskus JD, Tian C, Fingleton E, Shen C, Chen X, Li Y, Myers SA, Badger JD, 2nd, Bemben MA, Herring BE, Roche KW (2019)
Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action
Cell Rep 29 :2944

Paskus JD, Tian C, Fingleton E, Shen C, Chen X, Li Y, Myers SA, Badger JD, 2nd, Bemben MA, Herring BE, Roche KW (2019)
Cell Rep 29 :2944