| Title : Genetic and biochemical studies of the highly active esterases A' and B associated with organophosphate resistance in mosquitoes of the Culex pipiens complex - Pasteur_1981_Biochem.Genet_19_909 |
| Author(s) : Pasteur N , Iseki A , Georghiou GP |
| Ref : Biochemical Genetics , 19 :909 , 1981 |
|
Abstract :
The highly active esterases A' and B that cannot be dissociated from OP resistance in Culex pipiens from France and California are shown to have equivalent Km values (2.1 x 10(-6) M/min/mosquito) but different turnover rates (Vm = 2.13 and 0.57 x 10(-6) M/min/mosquito, respectively) and pH for maximum activity. Both enzymes have broad substrate specificities and at least one, esterase A', can hydrolyze OP insecticides. In addition, esterases A' and B are coded by two closely linked genes, Est-3 and Est-2, respectively (0.67 unit of crossing over), located on the same autosome as pl, a locus attributed to linkage group III. The estimated distance between Est-2 and pl was 9.4 units. |
| PubMedSearch : Pasteur_1981_Biochem.Genet_19_909 |
| PubMedID: 6120690 |
Pasteur N, Iseki A, Georghiou GP (1981)
Genetic and biochemical studies of the highly active esterases A' and B associated with organophosphate resistance in mosquitoes of the Culex pipiens complex
Biochemical Genetics
19 :909
Pasteur N, Iseki A, Georghiou GP (1981)
Biochemical Genetics
19 :909