| Title : Immunological distinction between acetylcholine receptor and the alpha-bungarotoxin-binding component on sympathetic neurons - Patrick_1977_Proc.Natl.Acad.Sci.U.S.A_74_4689 |
| Author(s) : Patrick J , Stallcup WB |
| Ref : Proc Natl Acad Sci U S A , 74 :4689 , 1977 |
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Abstract :
Clone PC12 of a rat sympathetic neuron cell line binds alpha-bungarotoxin and exhibits carbamoylcholine-stimulated uptake of sodium ions. Concentrations of alpha-bungarotoxin that saturate the alpha-bungarotoxin-binding site have no effect on agonist-stimulated sodium uptake. Conversely, antibodies against eel acetylcholine receptor block the agonist-induced sodium flux but fail to recognize the alpha-bungarotoxin-binding component. Detergent extracts of the PC12 clone inhibit the ability of antibody to eel acetylcholine receptor to recognize 125I-alpha-bungarotoxin-acetylcholine receptor complexes derived from muscle. These results distinguish between a ganglionic nicotinic acetylcholine receptor and an alpha-bungarotoxin-binding component on these cells, and provide evidence for antigenic similarities between muscle acetylcholine receptor and ganglionic acetylcholine receptor. |
| PubMedSearch : Patrick_1977_Proc.Natl.Acad.Sci.U.S.A_74_4689 |
| PubMedID: 270708 |
Patrick J, Stallcup WB (1977)
Immunological distinction between acetylcholine receptor and the alpha-bungarotoxin-binding component on sympathetic neurons
Proc Natl Acad Sci U S A
74 :4689
Patrick J, Stallcup WB (1977)
Proc Natl Acad Sci U S A
74 :4689