Title : Elettaria cardamomum (L.) Maton Essential Oil: An Interesting Source of Bioactive Specialized Metabolites as Inhibitors of Acetylcholinesterase and Butyrylcholinesterase - Pavarino_2023_Plants.(Basel)_12_ |
Author(s) : Pavarino M , Marengo A , Cagliero C , Bicchi C , Rubiolo P , Sgorbini B |
Ref : Plants (Basel) , 12 : , 2023 |
Abstract :
Elettaria cardamomum (L.) Maton (Zingiberaceae family) is a plant traditionally used in Ayurvedic and Chinese medicine. In this work, the essential oil of E. cardamomum was found to inhibit the enzymes AChE (62.6% of inhibition, IC(50) 24.9 microg/mL) and BChE (55.8% of inhibition, IC(50) 25.9 microg/mL) by performing an in vitro colorimetric assay using the Ellman method. A bio-guided fractionation approach was used to isolate fractions/pure compounds that were tested individually to evaluate their activity. The resulting oxygenated fraction was found to be active against both AChE (percentage inhibition 42.8%) and BChE (percentage inhibition 63.7%), while the hydrocarbon fraction was inactive. The activity was attributed to a pool of oxygenated terpenes (alpha-terpinyl acetate, 1,8-cineole, linalool, linalyl acetate, and alpha-terpineol) that synergistically contributed to the overall activity of the essential oil. |
PubMedSearch : Pavarino_2023_Plants.(Basel)_12_ |
PubMedID: 37836202 |
Pavarino M, Marengo A, Cagliero C, Bicchi C, Rubiolo P, Sgorbini B (2023)
Elettaria cardamomum (L.) Maton Essential Oil: An Interesting Source of Bioactive Specialized Metabolites as Inhibitors of Acetylcholinesterase and Butyrylcholinesterase
Plants (Basel)
12 :
Pavarino M, Marengo A, Cagliero C, Bicchi C, Rubiolo P, Sgorbini B (2023)
Plants (Basel)
12 :