| Title : Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection - Peck_2015_J.Virol_89_4696 |
| Author(s) : Peck KM , Cockrell AS , Yount BL , Scobey T , Baric RS , Heise MT |
| Ref : J Virol , 89 :4696 , 2015 |
|
Abstract :
Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. Mouse DPP4 (mDPP4) does not support MERS-CoV entry; however, changes at positions 288 and 330 can confer permissivity. Position 330 changes the charge and glycosylation state of mDPP4. We show that glycosylation is a major factor impacting DPP4 receptor function. These results provide insight into DPP4 species-specific differences impacting MERS-CoV host range and may inform MERS-CoV mouse model development. |
| PubMedSearch : Peck_2015_J.Virol_89_4696 |
| PubMedID: 25653445 |
Peck KM, Cockrell AS, Yount BL, Scobey T, Baric RS, Heise MT (2015)
Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection
J Virol
89 :4696
Peck KM, Cockrell AS, Yount BL, Scobey T, Baric RS, Heise MT (2015)
J Virol
89 :4696