Pejin_2017_Nat.Prod.Res__1

Reference

Title : The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity - Pejin_2017_Nat.Prod.Res__1
Author(s) : Pejin B , Tesanovic K , Jakovljevic D , Kaisarevic S , Sibul F , Raseta M , Karaman M
Ref : Nat Prod Res , :1 , 2017
Abstract :

The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 +/- 0.07 and 0.61 +/- 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained beta-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer's disease.

PubMedSearch : Pejin_2017_Nat.Prod.Res__1
PubMedID: 29166776

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Citations formats

Pejin B, Tesanovic K, Jakovljevic D, Kaisarevic S, Sibul F, Raseta M, Karaman M (2017)
The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity
Nat Prod Res :1

Pejin B, Tesanovic K, Jakovljevic D, Kaisarevic S, Sibul F, Raseta M, Karaman M (2017)
Nat Prod Res :1