| Title : Synthesis of 6beta-D-glucosyl and 6-nitroxy (-)-galanthamine derivatives as acetylcholinesterase inhibitors - Perissutti_2007_Pharmazie_62_403 |
| Author(s) : Perissutti E , Fiorino F , Severino B , Frecentese F , Massarelli P , Nencini C , Santagada V , Caliendo G |
| Ref : Pharmazie , 62 :403 , 2007 |
|
Abstract :
Galanthamine is an alkaloid approved for the treatment of Alzheimer's disease. In this paper the syntheses and the anticholinesterase activities of new glucosyl and nitroxy derivatives substituted on position 6 are reported. Compounds 2, 3 and 5 presented a percentage of inhibition of 35.22%, 47.48% and 67.89% respectively. |
| PubMedSearch : Perissutti_2007_Pharmazie_62_403 |
| PubMedID: 17663183 |
Perissutti E, Fiorino F, Severino B, Frecentese F, Massarelli P, Nencini C, Santagada V, Caliendo G (2007)
Synthesis of 6beta-D-glucosyl and 6-nitroxy (-)-galanthamine derivatives as acetylcholinesterase inhibitors
Pharmazie
62 :403
Perissutti E, Fiorino F, Severino B, Frecentese F, Massarelli P, Nencini C, Santagada V, Caliendo G (2007)
Pharmazie
62 :403