| Title : Thioamide-based fluorescent sensors for dipeptidyl peptidase 4 - Phan_2024_Chem.Commun.(Camb)__ |
| Author(s) : Phan HAT , Chang Y , Eaton SA , Petersson EJ |
| Ref : Chem Commun (Camb) , : , 2024 |
|
Abstract :
Dipeptidyl peptidase 4 (DPP-4) is a promising biomarker for cancer and metabolic diseases. We demonstrate the design of novel fluorescent DPP-4 probes based on the protease's native substrates using a thioamide as a quencher for measuring in vitro kinetics, inhibition with sitagliptin, and DPP-4 activity in saliva samples. |
| PubMedSearch : Phan_2024_Chem.Commun.(Camb)__ |
| PubMedID: 39439401 |
Phan HAT, Chang Y, Eaton SA, Petersson EJ (2024)
Thioamide-based fluorescent sensors for dipeptidyl peptidase 4
Chem Commun (Camb)
:
Phan HAT, Chang Y, Eaton SA, Petersson EJ (2024)
Chem Commun (Camb)
: