| Title : Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model - Pohl_2024_MicroPubl.Biol_2024_ |
| Author(s) : Pohl F , Lindsay-McGee V , Kong Thoo Lin P , Maciel P , Teixeira-Castro A |
| Ref : MicroPubl Biol , 2024 : , 2024 |
| Abstract : Inhibition of acetylcholinesterase (AChE) is a common used treatment option for Alzheimer's disease. However, there has been limited research on the potential use of AChE inhibitors for the treatment of Machado-Joseph disease (MJD)/Spinocerebellar Ataxia 3 (SCA3), in spite of the positive results using AChE inhibitors in patients with other inherited ataxias. MJD/SCA3, the most common form of dominant Spinocerebellar Ataxia worldwide, is caused by an expansion of the polyglutamine tract within the ataxin-3 protein, and is characterized by motor impairments. Our study shows that administration of the AChE inhibitor neostigmine is beneficial in treating the locomotion defective phenotype of a SCA3/MJD model of C. elegans and highlights the potential contribution of AChE enzymes to mutant ataxin-3-mediated toxicity. |
| ESTHER : Pohl_2024_MicroPubl.Biol_2024_ |
| PubMedSearch : Pohl_2024_MicroPubl.Biol_2024_ |
| PubMedID: 38404918 |
Pohl F, Lindsay-McGee V, Kong Thoo Lin P, Maciel P, Teixeira-Castro A (2024)
Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model
MicroPubl Biol
2024 :
Pohl F, Lindsay-McGee V, Kong Thoo Lin P, Maciel P, Teixeira-Castro A (2024)
MicroPubl Biol
2024 :