Title : OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii - Poirel_2005_Antimicrob.Agents.Chemother_49_202 |
Author(s) : Poirel L , Marque S , Heritier C , Segonds C , Chabanon G , Nordmann P |
Ref : Antimicrobial Agents & Chemotherapy , 49 :202 , 2005 |
Abstract :
A carbapenem-resistant Acinetobacter baumannii strain was isolated in Toulouse, France, in 2003. Cloning and expression in Escherichia coli identified the carbapenem-hydrolyzing beta-lactamase OXA-58, which is weakly related (less than 50% amino acid identity) to other oxacillinases. It hydrolyzed penicillins, oxacillin, and imipenem but not expanded-spectrum cephalosporins. The bla(OXA-58) gene was located on a ca. 30-kb non-self-transferable plasmid. After electrotransformation in the A. baumannii CIP7010(T) reference strain, it conferred reduced susceptibility to carbapenems. The bla(OXA-58) gene was bracketed by two novel ISAba3-like insertion elements. This study describes a newly characterized beta-lactamase that may contribute to carbapenem resistance in A. baumannii. |
PubMedSearch : Poirel_2005_Antimicrob.Agents.Chemother_49_202 |
PubMedID: 15616297 |
Gene_locus related to this paper: aciba-q2tr54 |
Gene_locus | aciba-q2tr54 |
Poirel L, Marque S, Heritier C, Segonds C, Chabanon G, Nordmann P (2005)
OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii
Antimicrobial Agents & Chemotherapy
49 :202
Poirel L, Marque S, Heritier C, Segonds C, Chabanon G, Nordmann P (2005)
Antimicrobial Agents & Chemotherapy
49 :202