| Title : Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production - Pollak_2005_Ann.Neurol_57_741 |
| Author(s) : Pollak Y , Gilboa A , Ben-Menachem O , Ben-Hur T , Soreq H , Yirmiya R |
| Ref : Annals of Neurology , 57 :741 , 2005 |
|
Abstract :
Overproduction of interleukin-1 within the brain is associated with Alzheimer's disease and other neurological conditions. We report that peripheral administration of the acetylcholinesterase inhibitors tacrine, rivastigmine, neostigmine, or EN101 (an antisense oligonucleotide directed at acetylcholinesterase messenger RNA) to mice significantly attenuated the production of interleukin-1beta in the hippocampus and blood, concomitantly with the reduction in acetylcholinesterase activity. These findings demonstrate that cholinergic enhancement produces central and peripheral antiinflammatory effects and suggest a novel therapeutic mechanism for acetylcholinesterase inhibitors. |
| PubMedSearch : Pollak_2005_Ann.Neurol_57_741 |
| PubMedID: 15852394 |
Pollak Y, Gilboa A, Ben-Menachem O, Ben-Hur T, Soreq H, Yirmiya R (2005)
Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production
Annals of Neurology
57 :741
Pollak Y, Gilboa A, Ben-Menachem O, Ben-Hur T, Soreq H, Yirmiya R (2005)
Annals of Neurology
57 :741