Pollard_1987_J.Pharm.Pharmacol_39_896

Reference

Title : The neuromuscular blocking effect of trimetaphan alone and in combination with different non-depolarizing muscle relaxants in the rat - Pollard_1987_J.Pharm.Pharmacol_39_896
Author(s) : Pollard BJ , van der Spek AF
Ref : J Pharm Pharmacol , 39 :896 , 1987
Abstract :

The effect of trimetaphan alone and in combination with pancuronium, tubocurarine or metocurine (dimethyl tubocurarine) has been examined on the rat phrenic nerve diaphragm preparation. Trimetaphan alone produced neuromuscular blockade in an all-or-none fashion once a concentration of between 2.39 X 10(-4) and 3.00 X 10(-4) M had been exceeded. Concentrations of trimetaphan below this threshold produced a dose-dependent potentiation of all three non-depolarizing relaxants studied. This potentiation was equal for tubocurarine and metocurine, but less for pancuronium.

PubMedSearch : Pollard_1987_J.Pharm.Pharmacol_39_896
PubMedID: 2892913

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Citations formats

Pollard BJ, van der Spek AF (1987)
The neuromuscular blocking effect of trimetaphan alone and in combination with different non-depolarizing muscle relaxants in the rat
J Pharm Pharmacol 39 :896

Pollard BJ, van der Spek AF (1987)
J Pharm Pharmacol 39 :896