Pollard_1988_Br.J.Anaesth_61_419

Reference

Title : Differing interactions between hexamethonium and tubocurarine, pancuronium or alcuronium at the neuromuscular junction - Pollard_1988_Br.J.Anaesth_61_419
Author(s) : Pollard BJ , van der Spek AF
Ref : British Journal of Anaesthesia , 61 :419 , 1988
Abstract :

The action of hexamethonium has been investigated in the rat phrenic nerve-hemidiaphragm preparation, alone and in combination with the neuromuscular blocking agents tubocurarine, pancuronium and alcuronium. Hexamethonium alone in concentrations between 3.55 x 10(-3) and 7.1 x 10(-3) mol litre-1 produced neuromuscular blockade in a dose-dependent manner. Low concentrations of hexamethonium antagonized the neuromuscular blocking effect of all three neuromuscular blocking drugs, less with tubocurarine than with the other two. Increasing the concentration of hexamethonium produced potentiation of the neuromuscular blocking effect, this being greater with tubocurarine than with either pancuronium or alcuronium. The cholinesterase activity in rat diaphragm homogenates was inhibited by hexamethonium. This inhibition was only significant at concentrations greater than those which resulted in antagonism and cannot, therefore, explain the observed antagonism. The mechanism of these observations is discussed with respect to the known behaviour of a combination of antagonists acting within a receptor system.

PubMedSearch : Pollard_1988_Br.J.Anaesth_61_419
PubMedID: 2903757

Related information

Citations formats

Pollard BJ, van der Spek AF (1988)
Differing interactions between hexamethonium and tubocurarine, pancuronium or alcuronium at the neuromuscular junction
British Journal of Anaesthesia 61 :419

Pollard BJ, van der Spek AF (1988)
British Journal of Anaesthesia 61 :419