Pompermaier_2022_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_257_109328

Reference

Title : Impaired initial development and behavior in zebrafish exposed to environmentally relevant concentrations of widely used pesticides - Pompermaier_2022_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_257_109328
Author(s) : Pompermaier A , Varela ACC , Mozzato MT , Soares SM , Fortuna M , Alves C , Tamagno WA , Barcellos LJG
Ref : Comparative Biochemistry & Physiology C Toxicol Pharmacol , 257 :109328 , 2022
Abstract :

Pesticides reach water bodies through different routes, either owing to incorrect packaging disposal, direct application to control macrophytes, leaching from fields, or natural degradation processes. In the aquatic environment, adverse effects in non-target species that come in contact with these substances are poorly understood. Currently, the most used pesticides are glyphosate (GBH) and 2,4-dichlorophenoxyacetic acid-based herbicides (DBH), as its presence in water bodies is already known, we used environmental concentrations and our exposure time comprised the entire period of organogenesis (3-120 h post-fertilization). We evaluated the response of embryos in their early development with the parameters of mortality, hatching, spontaneous movement, and heart rate; and it's through behavior the open field test and aversive stimulus, as well as biochemical analyzes of acetylcholinesterase activity (AChE), catalase (CTL) and superoxide dismutase (SOD) as a possible mechanism of action. Exposure to GBH decreased survival, caused hypermobility and anxiolytic behavior, negatively affected the anti-predatory behavior of the larvae, and increases acetylcholinesterase activity, whereas exposure to DBH caused only slight hypermobility in the larvae and increases acetylcholinesterase activity. These changes may compromise the perpetuation of the species, the search for partners/food, and facilitate the action of predators, which can result in serious ecological consequences.

PubMedSearch : Pompermaier_2022_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_257_109328
PubMedID: 35292329

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Citations formats

Pompermaier A, Varela ACC, Mozzato MT, Soares SM, Fortuna M, Alves C, Tamagno WA, Barcellos LJG (2022)
Impaired initial development and behavior in zebrafish exposed to environmentally relevant concentrations of widely used pesticides
Comparative Biochemistry & Physiology C Toxicol Pharmacol 257 :109328

Pompermaier A, Varela ACC, Mozzato MT, Soares SM, Fortuna M, Alves C, Tamagno WA, Barcellos LJG (2022)
Comparative Biochemistry & Physiology C Toxicol Pharmacol 257 :109328