| Title : Initial sequence and comparative analysis of the cat genome - Pontius_2007_Genome.Res_17_1675 |
| Author(s) : Pontius JU , Mullikin JC , Smith DR , Lindblad-Toh K , Gnerre S , Clamp M , Chang J , Stephens R , Neelam B , Volfovsky N , Schaffer AA , Agarwala R , Narfstrom K , Murphy WJ , Giger U , Roca AL , Antunes A , Menotti-Raymond M , Yuhki N , Pecon-Slattery J , Johnson WE , Bourque G , Tesler G , O'Brien SJ |
| Ref : Genome Res , 17 :1675 , 2007 |
| Abstract : The genome sequence (1.9-fold coverage) of an inbred Abyssinian domestic cat was assembled, mapped, and annotated with a comparative approach that involved cross-reference to annotated genome assemblies of six mammals (human, chimpanzee, mouse, rat, dog, and cow). The results resolved chromosomal positions for 663,480 contigs, 20,285 putative feline gene orthologs, and 133,499 conserved sequence blocks (CSBs). Additional annotated features include repetitive elements, endogenous retroviral sequences, nuclear mitochondrial (numt) sequences, micro-RNAs, and evolutionary breakpoints that suggest historic balancing of translocation and inversion incidences in distinct mammalian lineages. Large numbers of single nucleotide polymorphisms (SNPs), deletion insertion polymorphisms (DIPs), and short tandem repeats (STRs), suitable for linkage or association studies were characterized in the context of long stretches of chromosome homozygosity. In spite of the light coverage capturing approximately 65% of euchromatin sequence from the cat genome, these comparative insights shed new light on the tempo and mode of gene/genome evolution in mammals, promise several research applications for the cat, and also illustrate that a comparative approach using more deeply covered mammals provides an informative, preliminary annotation of a light (1.9-fold) coverage mammal genome sequence. |
| ESTHER : Pontius_2007_Genome.Res_17_1675 |
| PubMedSearch : Pontius_2007_Genome.Res_17_1675 |
| PubMedID: 17975172 |
| Gene_locus related to this paper: felca-ACHE , felca-CAUXIN , felca-CES1 , felca-m3vum5 , felca-m3w105 , felca-m3w106 , felca-m3w623 , felca-m3wld2 , felca-m3wq05 , felca-m3x0i6 , felca-m3x096 , felca-m3vyz9 , felca-m3w1s0 , felca-m3wf48 , felca-m3wfh7 , felca-m3xc81 , felca-m3xd05 , felca-m3w9k2 , felca-m3wqj7 , felca-m3wv14 , felca-m3x3n8 , felca-m3x4v9 , felca-a0a2i2ugd3 , felca-m3w8t2 , felca-lipp , felca-m3vwt0 , felca-m3wps6 , felca-m3xdn1 , felca-m3w589 , felca-m3wgf7 , felca-m3wgs3 , felca-m3w2b0 , felca-m3vvu0 , felca-m3x2j4 , felca-m3x850 , felca-a0a2i2u7a2 , felca-m3wja7 , felca-m3w2r7 , felca-m3vz31 , felca-m3wmt0 , felca-m3x3u3 , felca-a0a337s3d4 , felca-m3x0w7 |
| Gene_locus related to this paper: felca-ACHE , felca-CAUXIN , felca-CES1 , felca-m3vum5 , felca-m3w105 , felca-m3w106 , felca-m3w623 , felca-m3wld2 , felca-m3wq05 , felca-m3x0i6 , felca-m3x096 , felca-m3vyz9 , felca-m3w1s0 , felca-m3wf48 , felca-m3wfh7 , felca-m3xc81 , felca-m3xd05 , felca-m3w9k2 , felca-m3wqj7 , felca-m3wv14 , felca-m3x3n8 , felca-m3x4v9 , felca-a0a2i2ugd3 , felca-m3w8t2 , felca-lipp , felca-m3vwt0 , felca-m3wps6 , felca-m3xdn1 , felca-m3w589 , felca-m3wgf7 , felca-m3wgs3 , felca-m3w2b0 , felca-m3vvu0 , felca-m3x2j4 , felca-m3x850 , felca-a0a2i2u7a2 , felca-m3wja7 , felca-m3w2r7 , felca-m3vz31 , felca-m3wmt0 , felca-m3x3u3 , felca-a0a337s3d4 , felca-m3x0w7 |
Pontius JU, Mullikin JC, Smith DR, Lindblad-Toh K, Gnerre S, Clamp M, Chang J, Stephens R, Neelam B, Volfovsky N, Schaffer AA, Agarwala R, Narfstrom K, Murphy WJ, Giger U, Roca AL, Antunes A, Menotti-Raymond M, Yuhki N, Pecon-Slattery J, Johnson WE, Bourque G, Tesler G, O'Brien SJ (2007)
Initial sequence and comparative analysis of the cat genome
Genome Res
17 :1675
Pontius JU, Mullikin JC, Smith DR, Lindblad-Toh K, Gnerre S, Clamp M, Chang J, Stephens R, Neelam B, Volfovsky N, Schaffer AA, Agarwala R, Narfstrom K, Murphy WJ, Giger U, Roca AL, Antunes A, Menotti-Raymond M, Yuhki N, Pecon-Slattery J, Johnson WE, Bourque G, Tesler G, O'Brien SJ (2007)
Genome Res
17 :1675