Pyun_2012_Genomics.Inform_10_88

Lipoprotein lipase LPL plays an essential role in the regulation of high-density lipoprotein cholesterol HDLC and triglyceride levels which have been closely associated with cardiovascular diseases Genetic studies in European have shown that LPL single-nucleotide polymorphisms SNPs are strongly associated with lipid levels However studies about the influence of interactions between LPL SNPs and lifestyle factors have not been sufficiently performed Here we examine if LPL polymorphisms as well as their interaction with lifestyle factors influence lipid concentrations in a Korean population A two-stage association study was performed using genotype data for SNPs on the LPL gene including the 3 flanking region from 7,536 stage 1 and 3,703 stage 2 individuals The association study showed that 15 SNPs and 4 haplotypes were strongly associated with HDLC lowest p 2.86 x 10(-22 and triglyceride levels lowest p 3.0 x 10(-15 Interactions between LPL polymorphisms and lifestyle factors lowest p 9.6 x 10(-4 were also observed on lipid concentrations These findings suggest that there are interaction effects of LPL polymorphisms with lifestyle variables including energy intake fat intake smoking and alcohol consumption as well as effects of LPL polymorphisms themselves on lipid concentrations in a Korean population.