| Title : Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate - Qin_2019_Angew.Chem.Int.Ed.Engl_58_4291 |
| Author(s) : Qin XJ , Rauwolf TJ , Li PP , Liu H , McNeely J , Hua Y , Liu HY , Porco JA, Jr. |
| Ref : Angew Chem Int Ed Engl , 58 :4291 , 2019 |
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Abstract :
Rhodomyrtusials A-C, the first examples of triketone-sesquiterpene meroterpenoids featuring a unique 6/5/5/9/4 fused pentacyclic ring system were isolated from Rhodomyrtus tomentosa, along with several biogenetically-related dihydropyran isomers. Two bis-furans and one dihydropyran isomer showed acetylcholinesterase (AChE) inhibitory activity. Structures of the isolates were unambiguously established by a combination of spectroscopic data, ECD analysis, and total synthesis. Bioinspired total syntheses of six isolates were achieved in six steps utilizing a reactive enetrione intermediate generated in situ from a readily available hydroxy-endoperoxide precursor. |
| PubMedSearch : Qin_2019_Angew.Chem.Int.Ed.Engl_58_4291 |
| PubMedID: 30681258 |
Qin XJ, Rauwolf TJ, Li PP, Liu H, McNeely J, Hua Y, Liu HY, Porco JA, Jr. (2019)
Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate
Angew Chem Int Ed Engl
58 :4291
Qin XJ, Rauwolf TJ, Li PP, Liu H, McNeely J, Hua Y, Liu HY, Porco JA, Jr. (2019)
Angew Chem Int Ed Engl
58 :4291