Rabasseda_1987_FEBS.Lett_213_337

Reference

Title : ATP release from pure cholinergic synaptosomes is not blocked by tetanus toxin - Rabasseda_1987_FEBS.Lett_213_337
Author(s) : Rabasseda X , Solsona C , Marsal J , Egea G , Bizzini B
Ref : FEBS Letters , 213 :337 , 1987
Abstract :

Tetanus toxin (TeTx) is a neurotransmission impairing toxin that acts on several neurotransmitter systems. TeTx also inhibits the K+-induced release of acetylcholine (ACh) from synaptosomes isolated from the electric organ of Torpedo. Neither the membrane potential and depolarization, nor the depolarization-induced calcium uptake into cholinergic nerve terminals is modified after TeTx poisoning. On the other hand, it is known that, when cholinergic nerve terminals are stimulated, there is a release of ATP associated with the release of ACh. We have explored the action of TeTx on this co-release, and have found that there is no action of TeTx on the nucleotide release. Thus, TeTx blocks ACh release without modifying ATP release.

PubMedSearch : Rabasseda_1987_FEBS.Lett_213_337
PubMedID: 3556585

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Citations formats

Rabasseda X, Solsona C, Marsal J, Egea G, Bizzini B (1987)
ATP release from pure cholinergic synaptosomes is not blocked by tetanus toxin
FEBS Letters 213 :337

Rabasseda X, Solsona C, Marsal J, Egea G, Bizzini B (1987)
FEBS Letters 213 :337