| Title : Chemical composition, seasonal variation and antiaging activities of essential oil from Callistemon subulatus leaves growing in Egypt - Rabie_2023_J.Enzyme.Inhib.Med.Chem_38_2224944 |
| Author(s) : Rabie O , El-Nashar HAS , Majrashi TA , Al-Warhi T , El Hassab MA , Eldehna WM , Mostafa NM |
| Ref : J Enzyme Inhib Med Chem , 38 :2224944 , 2023 |
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Abstract :
Callistemon is an aromatic genus of flowering plants belonging to family Myrtaceae. The essential oils of C. subulatus leaves were collected in four seasons and analyzed using GC/MS. The oils demonstrated monoterpenes as the predominant class. Eucalyptol was the main component in all seasons; summer (66.87%), autumn (58.33%), winter (46.74%) and spring (44.63%), followed by alpha-pinene; spring (31.41%), winter (28.69%), summer (26.34%) and autumn (24.68%). Winter oil, the highest yield (0.53 mL/100g), was further investigated for its inhibitory activity against enzymes associated with ageing; elastase and acetylcholinesterase. It remarkably inhibited elastase and acetylcholinesterase with IC(50) values of 1.05 and 0.20 microg/ml, respectively. A molecular docking study was conducted for the major oil components on the active sites of target enzymes. Eucalyptol revealed the best binding affinity for both enzymes. C. subualtus oil could be used as supplement for management of ageing disorders like skin wrinkles and dementia. |
| PubMedSearch : Rabie_2023_J.Enzyme.Inhib.Med.Chem_38_2224944 |
| PubMedID: 37369580 |
Rabie O, El-Nashar HAS, Majrashi TA, Al-Warhi T, El Hassab MA, Eldehna WM, Mostafa NM (2023)
Chemical composition, seasonal variation and antiaging activities of essential oil from Callistemon subulatus leaves growing in Egypt
J Enzyme Inhib Med Chem
38 :2224944
Rabie O, El-Nashar HAS, Majrashi TA, Al-Warhi T, El Hassab MA, Eldehna WM, Mostafa NM (2023)
J Enzyme Inhib Med Chem
38 :2224944