| Title : Endogenous noradrenaline release from guinea-pig isolated trachea is inhibited by activation of M2 receptors - Racke_1992_Br.J.Pharmacol_107_3 |
| Author(s) : Racke K , Hey C , Wessler I |
| Ref : British Journal of Pharmacology , 107 :3 , 1992 |
|
Abstract :
Overflow of endogenous noradrenaline (NA) from guinea-pig isolated tracheae was evoked by electrical field stimulation (3 Hz, 540 pulses). The muscarinic receptor agonist oxotremorine inhibited the evoked overflow of NA in a concentration-dependent manner (EC50 84 nM). Methoctramine, pirenzepine and p-fluoro-hexahydrosiladiphenidol (each 1 microM) shifted the concentration-response curves of oxotremorine to the right with apparent pA2 values of 7.60, 6.74 and 6.18, respectively. It is concluded that sympathetic nerve terminals in the guinea-pig trachea are endowed with inhibitory muscarinic M2 receptors. |
| PubMedSearch : Racke_1992_Br.J.Pharmacol_107_3 |
| PubMedID: 1422576 |
Racke K, Hey C, Wessler I (1992)
Endogenous noradrenaline release from guinea-pig isolated trachea is inhibited by activation of M2 receptors
British Journal of Pharmacology
107 :3
Racke K, Hey C, Wessler I (1992)
British Journal of Pharmacology
107 :3