| Title : Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities - Ramli_2014_J.Nat.Prod_77_894 |
| Author(s) : Ramli RA , Lie W , Pyne SG |
| Ref : Journal of Natural Products , 77 :894 , 2014 |
|
Abstract :
Four new stichoneurine-type alkaloids, stichoneurines F and G (1-2) and sessilistemonamines E and F (3-4), have been isolated from the root extracts of Stichoneuron caudatum. The structures and relative configurations of these alkaloids have been determined by spectroscopic methods and molecular modeling experiments. Compounds 1-4 were tested for their acetylcholinesterase (AChE) inhibitory activities against human AChE. Compound 3 showed significant inhibitory activity with an IC50 value of 9.1+/-0.15 muM. |
| PubMedSearch : Ramli_2014_J.Nat.Prod_77_894 |
| PubMedID: 24606395 |
Ramli RA, Lie W, Pyne SG (2014)
Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities
Journal of Natural Products
77 :894
Ramli RA, Lie W, Pyne SG (2014)
Journal of Natural Products
77 :894