| Title : Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602 - Rascher_2003_FEMS.Microbiol.Lett_218_223 |
| Author(s) : Rascher A , Hu Z , Viswanathan N , Schirmer A , Reid R , Nierman WC , Lewis M , Hutchinson CR |
| Ref : FEMS Microbiology Letters , 218 :223 , 2003 |
|
Abstract :
We illustrate the use of a PCR-based method by which the genomic DNA of a microorganism can be rapidly queried for the presence of type I modular polyketide synthase genes to clone and characterize, by sequence analysis and gene disruption, a major portion of the geldanamycin production gene cluster from Streptomyces hygroscopicus var. geldanus NRRL 3602. |
| PubMedSearch : Rascher_2003_FEMS.Microbiol.Lett_218_223 |
| PubMedID: 12586396 |
| Gene_locus related to this paper: strhy-Q84G29 |
| Gene_locus | strhy-Q84G29 |
Rascher A, Hu Z, Viswanathan N, Schirmer A, Reid R, Nierman WC, Lewis M, Hutchinson CR (2003)
Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602
FEMS Microbiology Letters
218 :223
Rascher A, Hu Z, Viswanathan N, Schirmer A, Reid R, Nierman WC, Lewis M, Hutchinson CR (2003)
FEMS Microbiology Letters
218 :223