| Title : Pistagremic acid, a novel beta-secretase enzyme (BACE1) inhibitor from Pistacia integerrima Stewart - Rauf_2015_Nat.Prod.Res_29_1735 |
| Author(s) : Rauf A , Uddin G , Khan A , Siddiqui BS , Arfan M , Dalvandi K , Ben Hadda T |
| Ref : Nat Prod Res , 29 :1735 , 2015 |
|
Abstract :
A new triterpenic compound named pistagremic acid (PA) was once again isolated from Pistaciaintegerrima. The beta-secretase inhibition study was carried out. Compound PA was found significantly active against beta-secretase enzyme (BACE1) with IC50 value of 350 +/- 2 nM in comparison to the standard inhibitors [Asn670, Sta671, Val672]-amyloid-beta/A4 precursor protein 770 fragment 662-675 (IC50 = 290.71 +/- 1 nM). The selectivity of this compound was also evaluated against the acetylcholinesterase and butyrylcholinesterase enzymes. Interestingly compound PA was found to be inactive against them and showed selectivity towards beta-secretase enzyme (BACE1). |
| PubMedSearch : Rauf_2015_Nat.Prod.Res_29_1735 |
| PubMedID: 25588845 |
Rauf A, Uddin G, Khan A, Siddiqui BS, Arfan M, Dalvandi K, Ben Hadda T (2015)
Pistagremic acid, a novel beta-secretase enzyme (BACE1) inhibitor from Pistacia integerrima Stewart
Nat Prod Res
29 :1735
Rauf A, Uddin G, Khan A, Siddiqui BS, Arfan M, Dalvandi K, Ben Hadda T (2015)
Nat Prod Res
29 :1735