| Title : Novel animal-health drug targets from ligand-gated chloride channels - Raymond_2002_Nat.Rev.Drug.Discov_1_427 |
| Author(s) : Raymond V , Sattelle DB |
| Ref : Nat Rev Drug Discov , 1 :427 , 2002 |
|
Abstract :
The world's three best-selling veterinary antiparasitic drugs ('parasiticides') act on ligand-gated ion channels. The sequencing of the complete genomes of the invertebrate genetic model organisms Caenorhabditis elegans and Drosophila melanogaster has led to the recent cloning of new subunits of 5-hydroxytryptamine-gated and histamine-gated chloride channels. Together with L-glutamate-gated chloride channels, which are important targets of known parasiticides, and acetylcholine-gated chloride channels, these new classes of ligand-gated chloride channels, which are known only from invertebrates, add to our understanding of inhibitory neural signalling. They could offer the prospect of being targets for a new generation of selective drugs to control nematode and insect parasites. |
| PubMedSearch : Raymond_2002_Nat.Rev.Drug.Discov_1_427 |
| PubMedID: 12119744 |
Raymond V, Sattelle DB (2002)
Novel animal-health drug targets from ligand-gated chloride channels
Nat Rev Drug Discov
1 :427
Raymond V, Sattelle DB (2002)
Nat Rev Drug Discov
1 :427