| Title : Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines - Reale_2004_J.Neuroimmunol_148_162 |
| Author(s) : Reale M , Iarlori C , Gambi F , Feliciani C , Salone A , Toma L , DeLuca G , Salvatore M , Conti P , Gambi D |
| Ref : Journal of Neuroimmunology , 148 :162 , 2004 |
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Abstract :
Elevated levels of cytokines have been detected in brains of Alzheimer's disease (AD) patients, and altered peripheral levels of IL-1beta, TNFalpha and IL-6 have been reported in these patients. We studied the ability of PBMC from patients with AD, matched with a control group, to release pro- and anti-inflammatory cytokines, and the effect of AChEI treatment on cytokine release. Our data indicates that AChEI treatment down-regulates IL-1, IL-6 and TNF, and up-regulates the expression and production of IL-4 in PBMC in AD patients, and that AChEI leads to the remodelling of the cytokine network, probably acting on the lymphocytic cholinergic system. |
| PubMedSearch : Reale_2004_J.Neuroimmunol_148_162 |
| PubMedID: 14975597 |
Reale M, Iarlori C, Gambi F, Feliciani C, Salone A, Toma L, DeLuca G, Salvatore M, Conti P, Gambi D (2004)
Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines
Journal of Neuroimmunology
148 :162
Reale M, Iarlori C, Gambi F, Feliciani C, Salone A, Toma L, DeLuca G, Salvatore M, Conti P, Gambi D (2004)
Journal of Neuroimmunology
148 :162