Reece_1995_J.Clin.Pharmacol_35_526

Reference

Title : Lack of effect of tacrine administration on the anticoagulant activity of warfarin - Reece_1995_J.Clin.Pharmacol_35_526
Author(s) : Reece PA , Garnett WR , Rock WL, Jr. , Taylor JR , Underwood B , Sedman AJ , Rajagopalan R
Ref : Journal of Clinical Pharmacology , 35 :526 , 1995
Abstract :

The effect of tacrine administration on prothrombin time was studied in 13 patients receiving prolonged warfarin therapy. After a 3-week baseline period and 5 days of placebo administration, patients received 20 mg tacrine four times daily for 5 days. Prothrombin times were determined during baseline, daily before the morning doses of placebo and tacrine, and 14 days after the last tacrine dose (closeout). Mean (+/- SD) prothrombin times were 16.2 +/- 2.8 seconds at baseline, 15.1 +/- 2.6 seconds during the placebo phase, 15.8 +/- 3.6 seconds during the tacrine phase, and 15.3 +/- 3.6 seconds at closeout, indicating that tacrine has no effect on the anticoagulant activity of warfarin. Alteration of warfarin dosage should not be required in patients receiving concurrent tacrine therapy.

PubMedSearch : Reece_1995_J.Clin.Pharmacol_35_526
PubMedID: 7657855

Related information

Citations formats

Reece PA, Garnett WR, Rock WL, Jr., Taylor JR, Underwood B, Sedman AJ, Rajagopalan R (1995)
Lack of effect of tacrine administration on the anticoagulant activity of warfarin
Journal of Clinical Pharmacology 35 :526

Reece PA, Garnett WR, Rock WL, Jr., Taylor JR, Underwood B, Sedman AJ, Rajagopalan R (1995)
Journal of Clinical Pharmacology 35 :526