Title : Frequencies of five genetic polymorphisms in coronarographed patients and effects on lipid levels in a supposedly healthy population - Regis-Bailly_1996_Clin.Genet_50_339 |
Author(s) : Regis-Bailly A , Visvikis S , Steinmetz J , Feldmann L , Briancon S , Danchin N , Zannad F , Siest G |
Ref : Clin Genet , 50 :339 , 1996 |
Abstract :
Allele frequencies of genetic polymorphisms were compared between supposedly healthy subjects and angiographically proven coronary artery disease patients. The polymorphic candidate loci investigated were the apolipoprotein (apo) B signal peptide and XbaI polymorphism, the apo E polymorphism and two polymorphism of lipoprotein lipase (LPL) gene: Hind/III and PvuII. Apo B signal peptide and HindIII/LPL polymorphisms showed significant differences in allele partition between cases and controls; the rare alleles of both polymorphisms were less frequent (p < 0.05) in cases. We looked for associations between the polymorphisms and lipid concentration variability in a supposedly healthy population (145 men and 144 women). Apo B signal peptide, apo E and PvuII/LPL polymorphisms seem to influence some lipid metabolism parameters significantly. Apo AI and LpCIII levels were significantly different among apo B signal peptide genotypes: Del homozygotes had the highest concentrations of both variables. The epsilon 4 allele of apo E polymorphism was associated with increased concentrations of total cholesterol, LDL cholesterol and apo B. Increased LpAI:AII levels observed in E3 homozygotes (p < 0.01) have not previously been reported. LpAI:AII concentration was also influenced by PvuII/LPL polymorphisms. |
PubMedSearch : Regis-Bailly_1996_Clin.Genet_50_339 |
PubMedID: 9007321 |
Mutation | IVS8_495T>G_human-LPL |
Disease | Hyperlipoproteinemia TypeI |
Regis-Bailly A, Visvikis S, Steinmetz J, Feldmann L, Briancon S, Danchin N, Zannad F, Siest G (1996)
Frequencies of five genetic polymorphisms in coronarographed patients and effects on lipid levels in a supposedly healthy population
Clin Genet
50 :339
Regis-Bailly A, Visvikis S, Steinmetz J, Feldmann L, Briancon S, Danchin N, Zannad F, Siest G (1996)
Clin Genet
50 :339