| Title : Dendrotoxin-binding brain membrane protein displays a K+ channel activity that is stimulated by both cAMP-dependent and endogenous phosphorylations - Rehm_1989_Biochemistry_28_6455 |
| Author(s) : Rehm H , Pelzer S , Cochet C , Chambaz E , Tempel BL , Trautwein W , Pelzer D , Lazdunski M |
| Ref : Biochemistry , 28 :6455 , 1989 |
|
Abstract :
The purified protein that binds the K+ channel ligands dendrotoxin I and mast cell degranulating peptide can be phosphorylated by cAMP-dependent protein kinase and by an endogenous protein kinase, which may be a specific K+ channel kinase. Phosphorylations take place on the toxin-binding subunit, a polypeptide of 76-80 kDa. Phosphorylation by both kinases leads to activation of the reconstituted dendrotoxin-sensitive K+ channel. |
| PubMedSearch : Rehm_1989_Biochemistry_28_6455 |
| PubMedID: 2790006 |
Rehm H, Pelzer S, Cochet C, Chambaz E, Tempel BL, Trautwein W, Pelzer D, Lazdunski M (1989)
Dendrotoxin-binding brain membrane protein displays a K+ channel activity that is stimulated by both cAMP-dependent and endogenous phosphorylations
Biochemistry
28 :6455
Rehm H, Pelzer S, Cochet C, Chambaz E, Tempel BL, Trautwein W, Pelzer D, Lazdunski M (1989)
Biochemistry
28 :6455