| Title : Butyrylcholinesterase-knockout reduces brain deposition of fibrillar beta-amyloid in an Alzheimer mouse model - Reid_2015_Neurosci_298_424 |
| Author(s) : Reid GA , Darvesh S |
| Ref : Neuroscience , 298 :424 , 2015 |
|
Abstract :
In Alzheimer's disease (AD), numerous beta-amyloid (Abeta) plaques are associated with butyrylcholinesterase (BChE) activity, the significance of which is unclear. A mouse model, containing five human familial AD genes (5XFAD), also develops Abeta plaques with BChE activity. Knock-out of BChE in this model showed diminished fibrillar Abeta plaque deposition, more so in males than females. This suggests that lack of BChE reduces deposition of fibrillar Abeta in AD and this effect may be influenced by sex. |
| PubMedSearch : Reid_2015_Neurosci_298_424 |
| PubMedID: 25931333 |
Reid GA, Darvesh S (2015)
Butyrylcholinesterase-knockout reduces brain deposition of fibrillar beta-amyloid in an Alzheimer mouse model
Neuroscience
298 :424
Reid GA, Darvesh S (2015)
Neuroscience
298 :424