Ren_2016_Neurosci.Lett_619_73

Reference

Title : Meta-analyses of four polymorphisms of lipoprotein lipase associated with the risk of Alzheimer's disease - Ren_2016_Neurosci.Lett_619_73
Author(s) : Ren L , Ren X
Ref : Neuroscience Letters , 619 :73 , 2016
Abstract :

AIMS: We evaluated the contributions of four polymorphisms of the lipoprotein lipase (LPL) gene to the risk of Alzheimer's disease (AD).
METHODS: Through a comprehensive literature search for genetic variants of LPL involved in AD association studies, we found four polymorphisms for the current meta-analyses. These polymorphisms were Asn291Ser(rs268), PvuII(rs285), HindIII(rs320) and Ser447Ter(rs328).
RESULTS: In total, eight studies with 5064 cases and 5016 controls were retrieved for the meta-analyses of the four genetic variants. The analyses showed that Asn291Ser(rs268) (OR=2.34, 95% CI=1.05-5.25, P=0.04), HindIII(rs320) (OR=1.44, 95% CI=1.17-1.78, P=0.0006), and Ser447Ter(rs328) (OR=0.80, 95% CI=0.66-0.98, P=0.03) were significantly associated with a risk of AD. No association was found between the PvuII(rs285) polymorphism and the risk of AD.
CONCLUSIONS: Our results showed that Asn291Ser(rs268), HindIII(rs320) and Ser447Ter(rs328) polymorphisms of LPL were associated with a risk of AD. Asn291Ser(rs268) and HindIII(rs320) were predisposing factors of AD, whereas Ser447Ter(rs328) showed a protective effect for AD.

PubMedSearch : Ren_2016_Neurosci.Lett_619_73
PubMedID: 26975783

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Citations formats

Ren L, Ren X (2016)
Meta-analyses of four polymorphisms of lipoprotein lipase associated with the risk of Alzheimer's disease
Neuroscience Letters 619 :73

Ren L, Ren X (2016)
Neuroscience Letters 619 :73