Title : Vincamine, from an antioxidant and a cerebral vasodilator to its anticancer potential - Ren_2023_Bioorg.Med.Chem_92_117439 |
Author(s) : Ren Y , DeRose K , Li L , Gallucci JC , Yu J , Douglas Kinghorn A |
Ref : Bioorganic & Medicinal Chemistry , 92 :117439 , 2023 |
Abstract :
Vincamine is a naturally occurring indole alkaloid showing antioxidant activity and has been used clinically for the prevention and treatment of cerebrovascular disorders and insufficiencies. It has been well documented that antioxidants may contribute to cancer treatment, and thus, vincamine has been investigated recently for its potential antitumor activity. Vincamine was found to show cancer cell cytotoxicity and to modulate several important proteins involved in tumor growth, including acetylcholinesterase (AChE), mitogen-activated protein kinase (MAPK), nuclear factor-kappaB (NF-kappaB), nuclear factor erythroid 2-related factor 2 (Nrf2), and T-box 3 (TBX3). Several bisindole alkaloids, including vinblastine and vincristine and their synthetic derivatives, vindesine, vinflunine, and vinorelbine, have been used as clinically effective cancer chemotherapeutic agents. In the present review, the discovery and development of vincamine as a useful therapeutic agent and its antioxidant and antitumor activity are summarized, with its antioxidant-related mechanisms of anticancer potential being described. Also, discussed herein are the design of the potential vincamine-based oncolytic agents, which could contribute to the discovery of further new agents for cancer treatment. |
PubMedSearch : Ren_2023_Bioorg.Med.Chem_92_117439 |
PubMedID: 37579526 |
Ren Y, DeRose K, Li L, Gallucci JC, Yu J, Douglas Kinghorn A (2023)
Vincamine, from an antioxidant and a cerebral vasodilator to its anticancer potential
Bioorganic & Medicinal Chemistry
92 :117439
Ren Y, DeRose K, Li L, Gallucci JC, Yu J, Douglas Kinghorn A (2023)
Bioorganic & Medicinal Chemistry
92 :117439