Title : Circulating interleukin-15 in dementia disorders - Rentzos_2007_J.Neuropsychiatry.Clin.Neurosci_19_318 |
Author(s) : Rentzos M , Paraskevas GP , Kapaki E , Nikolaou C , Zoga M , Tsoutsou A , Rombos A , Vassilopoulos D |
Ref : J Neuropsychiatry Clin Neurosci , 19 :318 , 2007 |
Abstract :
The objective of this study was to assess the role of interleukin-15 (IL-15) as a potential marker of immune reactions in patients with Alzheimer's disease and vascular dementia. The authors measured by immunoassay serum IL-15 levels in 20 patients with Alzheimer's disease and 15 patients with vascular dementia and compared them with serum IL-15 levels in 15 healthy subjects. The authors also studied the effect of treatment with acetylcholinesterase inhibitors (AChEI) on serum IL-15 levels. Patients with Alzheimer's disease were found to have significantly lower serum IL-15 levels compared with healthy subjects and patients with vascular dementia. Healthy subjects and patients with vascular dementia did not differ between each other. Age, sex, disease duration, and Mini-Mental State Examination score did not affect IL-15 levels in any of the groups. Treatment with AChEI had no influence on IL-15 concentrations. The findings suggest that IL-15 is not implicated in the pathogenetic mechanisms of Alzheimer's disease and vascular dementia. An immune hyporesponsiveness at some point during disease development may be responsible for the lower levels of IL-15 and other cytokines in Alzheimer's disease patients. |
PubMedSearch : Rentzos_2007_J.Neuropsychiatry.Clin.Neurosci_19_318 |
PubMedID: 17827418 |
Rentzos M, Paraskevas GP, Kapaki E, Nikolaou C, Zoga M, Tsoutsou A, Rombos A, Vassilopoulos D (2007)
Circulating interleukin-15 in dementia disorders
J Neuropsychiatry Clin Neurosci
19 :318
Rentzos M, Paraskevas GP, Kapaki E, Nikolaou C, Zoga M, Tsoutsou A, Rombos A, Vassilopoulos D (2007)
J Neuropsychiatry Clin Neurosci
19 :318