| Title : Synthesis and acetylcholinesterase inhibitory activity of 2beta,3alpha-disulfoxy-5alpha-cholestan-6-one - Richmond_2011_Steroids_76_1160 |
| Author(s) : Richmond V , Garrido Santos GA , Murray AP , Maier MS |
| Ref : Steroids , 76 :1160 , 2011 |
|
Abstract :
Disodium 2beta,3alpha-dihydroxy-5alpha-cholestan-6-one disulfate (8) has been synthesized using cholesterol (1) as starting material. Sulfation was performed using trimethylamine-sulfur trioxide complex in dimethylformamide as the sulfating agent. The acetylcholinesterase inhibitory activity of compound 8 was evaluated and compared to that of disodium 2beta,3alpha-dihydroxy-5alpha-cholestane disulfate (10) and diols 7 and 9. Compounds 8 and 10 were active with IC(50) values of 14.59 and 59.65 muM, respectively. Diols 7 and 9 showed no inhibitory activity (IC(50)>500 muM). |
| PubMedSearch : Richmond_2011_Steroids_76_1160 |
| PubMedID: 21640741 |
Richmond V, Garrido Santos GA, Murray AP, Maier MS (2011)
Synthesis and acetylcholinesterase inhibitory activity of 2beta,3alpha-disulfoxy-5alpha-cholestan-6-one
Steroids
76 :1160
Richmond V, Garrido Santos GA, Murray AP, Maier MS (2011)
Steroids
76 :1160