Title : Autosomal recessive inheritance of congenital goiter in Afrikander cattle - Ricketts_1985_J.Hered_76_12 |
Author(s) : Ricketts MH , Schulz K , van Zyl A , Bester AJ , Boyd CD , Meinhold H , Van Jaarsveld PP |
Ref : Journal of Heredity , 76 :12 , 1985 |
Abstract :
Congenital goiter was reported in a number of herds of Afrikander cattle in the 1950's. Some affected animals were assembled and maintained as a closed herd. Although considerable biochemical research into the nature of the disease has been conducted, no definitive report has described the mode of inheritance of the defect. This paper presents the results of breeding studies that indicate the defect is inherited as an autosomal recessive. Southern blot analysis of the thyroglobulin gene confirms this finding. In addition, serum levels of TSH (thyroid stimulating hormone, thyrotropin), T3 (3,4,3'-tri-iodothyronine), T4 (thyroxine), rT3 (3,3',5'-tri-iodothyronine), and DIT (diiodotyrosine) of goitrous animals are compared with normal animals. |
PubMedSearch : Ricketts_1985_J.Hered_76_12 |
PubMedID: 3980970 |
Ricketts MH, Schulz K, van Zyl A, Bester AJ, Boyd CD, Meinhold H, Van Jaarsveld PP (1985)
Autosomal recessive inheritance of congenital goiter in Afrikander cattle
Journal of Heredity
76 :12
Ricketts MH, Schulz K, van Zyl A, Bester AJ, Boyd CD, Meinhold H, Van Jaarsveld PP (1985)
Journal of Heredity
76 :12