| Title : Regulation of synaptic stability by AMPA receptor reverse signaling - Ripley_2011_Proc.Natl.Acad.Sci.U.S.A_108_367 |
| Author(s) : Ripley B , Otto S , Tiglio K , Williams ME , Ghosh A |
| Ref : Proc Natl Acad Sci U S A , 108 :367 , 2011 |
| Abstract : The establishment of neuronal circuits relies on the stabilization of functionally appropriate connections and the elimination of inappropriate ones. Here we report that postsynaptic AMPA receptors play a critical role in regulating the stability of glutamatergic synapses. Removal of surface AMPA receptors leads to a decrease in the number and stability of excitatory presynaptic inputs, whereas overexpression increases synapse number and stability. Furthermore, overexpression of AMPA receptors along with Neuroligin-1 in 293T cells is sufficient to stabilize presynaptic inputs from cortical neurons onto heterologous cells. The stabilization of presynaptic inputs by AMPA receptors is not dependent on receptor-mediated current and instead relies on structural interactions mediated by the N-terminal domain of the glutamate receptor 2 (GluR2) subunit. These observations indicate that transsynaptic signaling mediated by the extracellular domain of GluR2 regulates the stability of presynaptic terminals. |
| ESTHER : Ripley_2011_Proc.Natl.Acad.Sci.U.S.A_108_367 |
| PubMedSearch : Ripley_2011_Proc.Natl.Acad.Sci.U.S.A_108_367 |
| PubMedID: 21173224 |
Ripley B, Otto S, Tiglio K, Williams ME, Ghosh A (2011)
Regulation of synaptic stability by AMPA receptor reverse signaling
Proc Natl Acad Sci U S A
108 :367
Ripley B, Otto S, Tiglio K, Williams ME, Ghosh A (2011)
Proc Natl Acad Sci U S A
108 :367