Rishitha_2021_Alzheimers.Dement_17 Suppl 12_e058344

BACKGROUND: Alpha napthoflavone (ANF) is a flavonoid compound it is also know as Alpha- 7,8-benzoflavone, it is a natural flavone available in Russian knapweed in larger quantity. Pharmacologically, it is also reported to produce the cardioprotection, neuroprotection including anti-Alzheimer actions. It possesses multiple cellular actions like anti-oxidant, anti-inflammatory, and anti-apoptotic actions. However, the role of ANF in vascular dementia (VaD) not explored yet. METHOD: VaD was induced by i.c.v. injection of L-Cys in rats. The test compounds i.e., ANF (40 and 80 mg/kg; p.o.) and reference drug i.e., donepezil (10 mg/kg; p.o.) were administered for 5 consecutive days. The behavioral assessment i.e., learning and memory functions were evaluated by Morris water maze (MWM) test. In addition, the biochemical markers i.e., acetylcholinesterase (AChE) activity; lipid peroxidation (LPO) and homocysteine (HCy) levels were estimated in hippocampal tissue samples RESULT: ANF shown ameliorative effect against i.c.v. injection of L-Cys induced VaD in rats via reduction of AChE activity, LPO and HCy levels CONCLUSION: ANF may be a newer candidate from herbal origin for the management of cerebrovascular disorders like stroke and vascular dementia.