| Title : Amelioration by glucose-6-phosphate and NADP of potato glycoalkaloid inhibition in cell, enzyme and liposome assays - Roddick_1999_Phytochemistry_51_23 |
| Author(s) : Roddick JG , Leonard AL |
| Ref : Phytochemistry , 51 :23 , 1999 |
| Abstract : Lysis of human erythrocytes by 20 microM chaconine was reduced by 0.5 mM glucose-6-phosphate (G6P) and NADP. Both compounds caused approximately 50% inhibition of haemolysis at 1 mM. Glucose, glucose-1-phosphate, rhamnose, galactose and galactose-6-phosphate were ineffective; NAD was effective, although not to the extent of NADP. Of the tested sugars, only G6P reduced solanine-induced haemolysis. G6P also reduced the synergistic haemolytic action of solanine and chaconine in combination. G6P and NADP at or above 5 mM antagonised chaconine-induced betanin loss from excised red beet root discs; NADP was more effective than G6P. Disruption of PC/cholesterol liposomes by chaconine and inhibition of acetylcholinesterase by chaconine or solanine, were unaffected by up to 10 mM NADP or 50 mM G6P. |
| ESTHER : Roddick_1999_Phytochemistry_51_23 |
| PubMedSearch : Roddick_1999_Phytochemistry_51_23 |
| PubMedID: 10349728 |
Roddick JG, Leonard AL (1999)
Amelioration by glucose-6-phosphate and NADP of potato glycoalkaloid inhibition in cell, enzyme and liposome assays
Phytochemistry
51 :23
Roddick JG, Leonard AL (1999)
Phytochemistry
51 :23