| Title : Preparation of nucleoside-carbohydrate phosphodiester prodrug analogues by chemoenzymatic procedure - Rodriguez-Perez_2008_Nucleic.Acids.Symp.Ser.(Oxf)__101 |
| Author(s) : Rodriguez-Perez T , Fernandez S , Sanghvi YS , Gotor V , Ferrero M |
| Ref : Nucleic Acids Symp Ser (Oxf) , :101 , 2008 |
|
Abstract :
An efficient synthesis protocol for the glucosyl-nucleoside phosphodiester derivatives has been developed. These mononucleotides were designed to act as pronucleotides with potential to deliver the parent compound as its monophosphate. Key step of the synthesis is the regioselective hydrolysis of peracetylated alpha-D-glucose catalyzed by Candida rugosa lipase. |
| PubMedSearch : Rodriguez-Perez_2008_Nucleic.Acids.Symp.Ser.(Oxf)__101 |
| PubMedID: 18776273 |
Rodriguez-Perez T, Fernandez S, Sanghvi YS, Gotor V, Ferrero M (2008)
Preparation of nucleoside-carbohydrate phosphodiester prodrug analogues by chemoenzymatic procedure
Nucleic Acids Symp Ser (Oxf)
:101
Rodriguez-Perez T, Fernandez S, Sanghvi YS, Gotor V, Ferrero M (2008)
Nucleic Acids Symp Ser (Oxf)
:101