| Title : The structural gene for microcin H47 encodes a peptide precursor with antibiotic activity - Rodriguez_1999_Antimicrob.Agents.Chemother_43_2176 |
| Author(s) : Rodriguez E , Gaggero C , Lavina M |
| Ref : Antimicrobial Agents & Chemotherapy , 43 :2176 , 1999 |
| Abstract : Microcin H47 is a bactericidal antibiotic produced by a naturally occurring Escherichia coli strain isolated in Uruguay. The microcin genetic system is located in the chromosome and extends over a 10-kb DNA segment containing the genes required for microcin synthesis, secretion, and immunity. The smallest microcin synthesis gene, mchB, was sequenced and shown to encode a highly hydrophobic peptide. An mchB-phoA gene fusion, which directed the synthesis of a hybrid bifunctional protein with both PhoA and microcin H47-like activities, was isolated. The results presented herein lead us to propose that microcin H47 is indeed a ribosomally synthesized peptide antibiotic and that its peptide precursor already has antibiotic activity of the same specificity as that of mature microcin. |
| ESTHER : Rodriguez_1999_Antimicrob.Agents.Chemother_43_2176 |
| PubMedSearch : Rodriguez_1999_Antimicrob.Agents.Chemother_43_2176 |
| PubMedID: 10471561 |
| Gene_locus related to this paper: ecoli-MCMK |
| Gene_locus related to this paper: ecoli-MCMK |
Rodriguez E, Gaggero C, Lavina M (1999)
The structural gene for microcin H47 encodes a peptide precursor with antibiotic activity
Antimicrobial Agents & Chemotherapy
43 :2176
Rodriguez E, Gaggero C, Lavina M (1999)
Antimicrobial Agents & Chemotherapy
43 :2176