Title : PET studies of the influences of nicotine on neural systems in cigarette smokers - Rose_2003_Am.J.Psychiatry_160_323 |
Author(s) : Rose JE , Behm FM , Westman EC , Mathew RJ , London ED , Hawk TC , Turkington TG , Coleman RE |
Ref : Am J Psychiatry , 160 :323 , 2003 |
Abstract :
OBJECTIVE: The effects of acute nicotine administration and smoking on brain function were investigated in two studies, with the primary goal of identifying neural systems that mediate these effects. METHOD: In study 1, 18 healthy volunteer cigarette smokers were exposed to three conditions in a single session: 1) smoking a nicotine-containing cigarette, 2) smoking a denicotinized cigarette, or 3) receiving intravenous nicotine injections in conjunction with smoking a denicotinized cigarette. In study 2, 16 subjects smoked a nicotine-containing and denicotinized cigarette in each of two sessions 2 hours after receiving the nicotinic antagonist mecamylamine (10 mg) or placebo orally. Regional cerebral blood flow (rCBF) was assessed by using the bolus (15)O-labeled water method and positron emission tomography. Subjective measures of smoking withdrawal symptoms were also collected. |
PubMedSearch : Rose_2003_Am.J.Psychiatry_160_323 |
PubMedID: 12562580 |
Rose JE, Behm FM, Westman EC, Mathew RJ, London ED, Hawk TC, Turkington TG, Coleman RE (2003)
PET studies of the influences of nicotine on neural systems in cigarette smokers
Am J Psychiatry
160 :323
Rose JE, Behm FM, Westman EC, Mathew RJ, London ED, Hawk TC, Turkington TG, Coleman RE (2003)
Am J Psychiatry
160 :323